HMGCR (NM_000859) Human Recombinant Protein

CAT#: TP762035

Purified recombinant protein of Human 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), transcript variant 1,Gln341-Glu620, with N-terminal His tag, expressed in E. coli, 50ug


USD 215.00

In Stock*

Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(Gln341-Glu620) of HMGCR
Tag N-His
Predicted MW 30.7 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol,1% Sarkosyl.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000850
Locus ID 3156
UniProt ID P04035, A0A024RAP2
Cytogenetics 5q13.3
Refseq Size 4471
Refseq ORF 2664
Synonyms LDLCQ3
Summary HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Metabolic pathways, Terpenoid backbone biosynthesis

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