DDB2 (NM_000107) Human Recombinant Protein

CAT#: TP762063

Purified recombinant protein of Human damage-specific DNA binding protein 2, 48kDa (DDB2),Met1-Leu250, with N-terminal His tag, expressed in E. coli, 50ug


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USD 215.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(Met1-Leu250) of DDB2
Tag N-His
Predicted MW 27.7 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, 8M Urea, pH8.0.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000098
Locus ID 1643
UniProt ID Q92466
Cytogenetics 11p11.2
Refseq Size 1870
Refseq ORF 1281
Synonyms DDBB; UV-DDB2; XPE
Summary 'This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]'
Protein Families Druggable Genome
Protein Pathways Nucleotide excision repair, p53 signaling pathway, Ubiquitin mediated proteolysis

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