NALP4 (NLRP4) (NM_134444) Human Recombinant Protein

CAT#: TP762168

Purified recombinant protein of Human NLR family, pyrin domain containing 4 (NLRP4),Met1-Tyr310, with N-terminal His tag, expressed in E.coli, 50ug


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USD 215.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(Met1-Tyr310) of NLRP4
Tag N-His
Predicted MW 36.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, 8M Urea, pH8.0.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_604393
Locus ID 147945
UniProt ID Q96MN2, B2RCA1
Cytogenetics 19q13.43
Refseq Size 3339
Refseq ORF 2982
Synonyms CLR19.5; CT58; NALP4; PAN2; PYPAF4; RNH2
Summary The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]

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