ADAMTS5 (NM_007038) Human Recombinant Protein

CAT#: TP762212

Purified recombinant protein of Human ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5), His346-Pro622, with N-terminal His tag, expressed in E.coli, 50ug


USD 205.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(His346-Pro622) of ADAMTS5
Tag N-His
Predicted MW 30.4 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, 8M Urea, pH8.0.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_008969
Locus ID 11096
UniProt ID Q9UNA0
Cytogenetics 21q21.3
Refseq Size 9663
Refseq ORF 2790
Synonyms ADAM-TS 5; ADAM-TS5; ADAM-TS 11; ADAMTS-5; ADAMTS-11; ADAMTS11; ADMP-2
Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome, Protease, Secreted Protein

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