DOCK2 (NM_004946) Human Recombinant Protein

CAT#: TP762218

Purified recombinant protein of Human dedicator of cytokinesis 2 (DOCK2), Ala1544-End, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein DOCK2 was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region(Ala1544-End) of DOCK2
• Tag: N-His
• Predicted MW: 32.5 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50mM Tris, 8M Urea, pH8.0.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_004937
• Locus ID: 1794
• UniProt ID: Q92608, Q5XG91
• Cytogenetics: 5q35.1
• Refseq Size: 6050
• Refseq ORF: 5490
• Synonyms: IMD40
• Summary: 'The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]'
• Protein Families: Druggable Genome
• Protein Pathways: Chemokine signaling pathway, Fc gamma R-mediated phagocytosis