DOCK2 (NM_004946) Human Recombinant Protein

CAT#: TP762218

Purified recombinant protein of Human dedicator of cytokinesis 2 (DOCK2), Ala1544-End, with N-terminal His tag, expressed in E.coli, 50ug


USD 205.00

In Stock*

Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(Ala1544-End) of DOCK2
Tag N-His
Predicted MW 32.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, 8M Urea, pH8.0.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_004937
Locus ID 1794
UniProt ID Q92608, Q5XG91
Cytogenetics 5q35.1
Refseq Size 6050
Refseq ORF 5490
Synonyms IMD40
Summary 'The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]'
Protein Families Druggable Genome
Protein Pathways Chemokine signaling pathway, Fc gamma R-mediated phagocytosis

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