Cellular Apoptosis Susceptibility (CSE1L) (NM_001316) Human Recombinant Protein

CAT#: TP762224

Purified recombinant protein of Human CSE1 chromosome segregation 1-like (yeast) (CSE1L), Met1-Leu300, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein CSE1L was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region(Met1-Leu300) of CSE1L
• Tag: N-His
• Predicted MW: 34.9 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50mM Tris, 8M Urea, pH8.0.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_001307
• Locus ID: 1434
• UniProt ID: P55060, A0A384NKW7
• Cytogenetics: 20q13.13
• Refseq Size: 3627
• Refseq ORF: 2913
• Synonyms: CAS; CSE1; XPO2
• Summary: 'Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]'
• Protein Families: Druggable Genome