CD49b (ITGA2) (NM_002203) Human Recombinant Protein

CAT#: TP762237

Purified recombinant protein of Human integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2), Asp203-Val466, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein ITGA2 was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region(Asp203-Val466) of ITGA2
• Tag: N-His
• Predicted MW: 28.6 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50mM Tris, 8M Urea, pH8.0.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_002194
• Locus ID: 3673
• UniProt ID: P17301
• Cytogenetics: 5q11.2
• Refseq Size: 5361
• Refseq ORF: 3543
• Synonyms: BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2
• Summary: 'This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]'
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer