TLR5 (NM_003268) Human Recombinant Protein

CAT#: TP762255

Purified recombinant protein of Human toll-like receptor 5 (TLR5), Leu258-Ser404, with N-terminal His-ABP tag, expressed in E.coli, 50ug


  View other "TLR5" proteins (4)

USD 205.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(Leu258-Ser404) of TLR5
Tag N-His ABP
Predicted MW 32.1 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, 8M Urea, pH8.0.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_003259
Locus ID 7100
UniProt ID O60602, A0A2R8Y7Z4
Cytogenetics 1q41
Refseq Size 3369
Refseq ORF 2574
Synonyms MELIOS; SLE1; SLEB1; TIL3
Summary 'This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]'
Protein Families Druggable Genome, Transmembrane
Protein Pathways Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway

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