TFPI (NM_006287) Human Recombinant Protein

CAT#: TP762302

Purified recombinant protein of Human tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) (TFPI), transcript variant 1, Asp29-End, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein TFPI was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region(Asp29-End) of TFPI
• Tag: N-His
• Predicted MW: 31.9 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50mM Tris, pH8.0, 8M Urea
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_006278
• Locus ID: 7035
• UniProt ID: P10646
• Cytogenetics: 2q32.1
• Refseq Size: 1431
• Refseq ORF: 912
• Synonyms: EPI; LACI; TFI; TFPI1
• Summary: 'This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]'
• Protein Families: Secreted Protein
• Protein Pathways: Complement and coagulation cascades