KIR2DL1 (NM_014218) Human Recombinant Protein

CAT#: TP762668

Purified recombinant protein of Human killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 (KIR2DL1), 25Val-240Asn, with N-terminal His tag, expressed in E.coli, 50ug


USD 261.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(25Val-240Asn) of KIR2DL1
Tag N-His
Predicted MW 23.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
Storage Store at -80°C after receiving vials.
Stability Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_055033
Locus ID 3802
UniProt ID P43626, Q6H2H3, Q6H2H2
Cytogenetics 19q13.42
Refseq Size 1593
Refseq ORF 1044
Synonyms CD158A; KIR-K64; KIR2DL3; KIR221; NKAT; NKAT-1; NKAT1; p58.1
Summary Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Protein Families Transmembrane
Protein Pathways Antigen processing and presentation, Graft-versus-host disease, Natural killer cell mediated cytotoxicity

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.