Prothrombin (F2) (NM_000506) Human Recombinant Protein

CAT#: TP790103

Purified recombinant protein of Human coagulation factor II (thrombin) (F2), esidues 44aa-end, with N-terminal His tag, expressed in human cells;


  View other "F2" proteins (5)

USD 425.00

In Stock*

Size
    • 50 ug

Product Images

Specifications

Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC208589, encoding the region Ala44-end of F2.
Tag N-His
Predicted MW 66.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 90% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS,pH7.4,10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000497
Locus ID 2147
UniProt ID P00734
Cytogenetics 11p11.2
Refseq Size 2018
Refseq ORF 1866
Synonyms PT; RPRGL2; THPH1
Summary 'This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020]'
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton

Documents

Other Versions

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.