MYBPC3 Mouse Monoclonal Antibody [Clone ID: OTI2D8D7]
CAT#: CF813811
Carrier-free (BSA/glycerol-free) MYBPC3 mouse monoclonal antibody, clone OTI2D8D7
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Transient overexpression lysate of myosin binding protein C, cardiac (MYBPC3)
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Specifications
Product Data | |
Clone Name | OTI2D8D7 |
Applications | ELISA |
Recommended Dilution | ELISA 1:5000-10000 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human MYBPC3(C0-C1) (NP_000247) produced in E.coli. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Predicted Protein Size | 140.8 kDa |
Gene Name | Homo sapiens myosin binding protein C3 (MYBPC3), mRNA. |
Database Link | |
Background | MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
Synonyms | CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
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