Amyloid beta (1-40 specific) Mouse Monoclonal Antibody [Clone ID: 5C3]

CAT#: AM00001FC-N

Amyloid beta (1-40 specific) mouse monoclonal antibody, clone 5C3, FITC

Specifications

Product Data

• Clone Name: 5C3
• Applications: IF
• Recommended Dilution: Immunocytochemistry: 1-10 μg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: C-terminal peptide conjugated to KLH
• Specificity: This antibody specifically interacts with the C-Terminus of β-Amyloid (1-40) and does not crossreact with β-Amyloid (1-42).
• Formulation: PBS containing 0.09% Sodium Azide/PEG and Sucrose
  Label: FITC
  State: Liquid purified IgG fraction
• Concentration: 0.5 mg/ml
• Purification: Size Exclusion Chromatography
• Conjugation: FITC
• Background: The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59).