STAT3 pTyr705 Mouse Monoclonal Antibody [Clone ID: 9E12]

CAT#: AM00148FC-N

STAT3 pTyr705 mouse monoclonal antibody, clone 9E12, FITC


USD 530.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 9E12
Applications IF
Recommended Dilution Immunocytochemistry: 1-10 µg/ml.
Reactivities Canine, Human, Mouse
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Phosphopeptide conjugated to KLH
Epitope: Phosphotyrosine 705...A P pY L K...
Specificity This antibody specifically recognizes STAT3 phosphorylated at Tyr705.
The antibody does not crossreact with the non-phosphorylated form of STAT3 nor with unrelated tyrosine-phosphorylated proteins.
Formulation PBS containing 0.09% Sodium Azide, PEG and Sucrose.
Label: FITC
State: Liquid purified IgG fraction
Concentration lot specific
Purification Subsequent Thiophilic Adsorption and Size Exclusion Chromatography
Conjugation FITC
Storage Aliquote and freeze in liquid nitrogen.
Avoid repeated freezing and thawing.
The antibody is stable at -80°C for one year.
Thaw aliquots at 37°C. Thawed aliquots may be stored at 2-8°C up to 3 months.
Predicted Protein Size 92 kDa
Background The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STATs are mediators involved in cytokine signalling. In response to a specific cytokine signal, STAT proteins are phosphorylated on conserved tyrosine residues. Phosphorylated STAT proteins dimerize via their SH2 domains and move to the nucleus.
The STAT dimers bind to specific DNA elements resulting in transcriptional regulation of downstream target genes. STAT3 is activated by tyrosine phosphorylation at residue Tyr 705 in cells treated with interleukin 6 or EGF. Activated STAT3 can bind to DNA either as homodimer or as heterodimer with STAT1.
Synonyms STAT-3, Acute-phase response factor, APRF
Note For Immunoblotting, Immunoprecipitation or ELISA, clone 9E12 is available as purified or Biotin-labelled antibody (Cat.no. AM00148PU-N or AM00148BT-N).
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.