Icam1 Rat Monoclonal Antibody [Clone ID: BE29G1]

CAT#: AM00701BT-N

Icam1 rat monoclonal antibody, clone BE29G1, Biotin

Specifications

Product Data

• Clone Name: BE29G1
• Applications: FC, IHC, IP
• Recommended Dilution: Flow Cytometry (1 µg / 1 x 10⁶ cells).
  Immunoprecipitation.
  Immunohistochemistry.
  Blocking: Blocks the binding of LFA-1 to ICAM-1.
  Suitable for studies of inflammation, lymphocyte differentiation, and lymphocyte activation.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: Recognizes the Mr 95 kDa cell surface glycoprotein known as intracellular adhesion molecule ICAM-1.
• Formulation: 0.01M PBS, pH 7.4 containing 2mM EDTA
  Label: Biotin
  State: Liquid purified Ig fraction
  Stabilizer: 1% BSA
  Preservative: 0.09% Sodium Azide
• Concentration: 0.5 mg/ml (OD280nm)
• Purification: Protein G Chromatography
• Conjugation: Biotin
• Database Link:
  Entrez Gene 15894 Mouse
• Background: ICAM1 is a 85-110 kDa single chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils), with lower levels that increase in inflammation. ICAM1 is also detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.
• Synonyms: ICAM-1
• Note: Centrifuge vial before opening.