Apolipoprotein A I (APOA1) Mouse Monoclonal Antibody [Clone ID: 057-16001]

CAT#: AM00801PU-N

Apolipoprotein A I (APOA1) mouse monoclonal antibody, clone 057-16001, Purified

Specifications

Product Data

• Clone Name: 057-16001
• Applications: ELISA, R
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Human High Density Lipoprotein.
• Specificity: This antibody recognizes Apolipoprotein A I.
  This product does not cross react with Apo AII or Apo B in competitive RIA.
• Formulation: 10mM Phosphate, pH 7.4 containing 150mM Sodium Chloride and 0.09% Sodium Azide
  State: Purified
  State: Liquid (0.2µm filtered) purified IgG fraction (>90% pure by SDS-PAGE).
• Concentration: lot specific
• Purification: Protein A Chromatography.
• Storage: Store the antibody undiluted at 2-8°C for one week or (in aliquots) at -20°C for longer.
  If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 335 Human
• Background: Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease.
  The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.
• Synonyms: APOA1, ApoA-I, Apo-AI, ApoAI
• Note: Centrifuge before opening to ensure complete recovery of vial contents.