PDPN Rat Monoclonal Antibody [Clone ID: NZ-1]

CAT#: AM01133PU-N

PDPN rat monoclonal antibody, clone NZ-1, Purified

Product Images

NZ-1 Staining of Human Mesothelial Cells.

Specifications

Product Data

• Clone Name: NZ-1
• Applications: FC, IHC, IP, WB
• Recommended Dilution: FACS: 1/200.
  Western blot: ≥ 1/200.
  Immunoprecipitation: 1/50.
  Immunostaining/Immunohistochemistry on Frozen and Paraffin Sections: 1/200.
• Reactivities: Human
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: The monoclonal antibody will detect Human Podoplanin on the surface of lymphatic endothelial cells and kidney podocytes. Therefore, it will be a useful tool to study lymphatic vessel density in and around Human tumors.
• Formulation: PBS
  State: Purified
  State: Liquid purified antibody
  Preservative: 0.09% Sodium Azide
• Concentration: 0.5 mg/ml
• Database Link:
  Entrez Gene 10630 Human
• Background: Podoplanin is a well-recognized lymphatic endothelium marker, which can be used to reliably distinguish lymphatic vessels from blood vessels. Podoplanin is a Mr 38,000 membrane mucoprotein that was originally detected on the surface of rat glomerular epithelial cells (podocytes) and was found to be linked to flattening of foot processes that occurs in glomerular diseases. Podoplanin shows features of a membrane mucoprotein with several conserved O-glycosylation sites. Currently, it is of unknown biological function. Because heavily O-glycosylated mucoproteins were identified recently as counterreceptors for selectins that mediate adhesion of inflammatory cells, it is possible that podoplanin plays a similar role in lymphatic endothelia.
• Synonyms: Glycoprotein 36, PA2.26 antigen, T1-alpha, Aggrus, PDPN, GP36, PSEC0003, PSEC0025