CD79A (202-216) Mouse Monoclonal Antibody [Clone ID: HM57]

CAT#: AM01322FC-N

CD79A (202-216) mouse monoclonal antibody, clone HM57, FITC


USD 270.00

5 Days*

Size
    • 100 Tests

Product Images

Specifications

Product Data
Clone Name HM57
Applications FC
Recommended Dilution Flow Cytometry analysis of human blood cells: 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension.
The content of a vial (0.4 ml) is sufficient for 100 tests.
Reactivities Bovine, Chicken, Equine, Guinea Pig, Human, Mouse, Opossum, Porcine, Rabbit, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Synthetic peptide corresponding to 202-216 amino acid sequence of Human mb-1.
Specificity This antibody interacts with CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
Formulation PBS
Label: FITC
State: Liquid purified IgG fraction
Stabilizer: 0.2% (w/v) BSA (high-grade protease free)
Preservative: 15 mM sodium azide
Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.
Conjugation FITC
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Background CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
Synonyms IGA, MB1, B-Cell marker
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.