DcR1 (TNFRSF10C) Mouse Monoclonal Antibody [Clone ID: 2B8]

CAT#: AM01323FC-N

DcR1 (TNFRSF10C) mouse monoclonal antibody, clone 2B8, FITC

Specifications

Product Data

• Clone Name: 2B8
• Applications: FC, IP
• Recommended Dilution: Flow cytometry (Neat - 1/10): use 10 µl of the suggested working dilution to label 1x10e6 cells in 100 µl.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: DcR1-Fc chimaeric protein. Lymph node cells from immunised mice were fused with cells of the P3U1 myeloma cell line.
• Specificity: This antibody recognises CD263, a 60 kD cell surface protein.
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
  Label: FITC
  State: Liquid purified IgG
  Label: Fluorescein Isothiocyanate Isomer 1
• Concentration: 0.1mg/ml
• Purification: Affinity chromatography on Protein G
• Conjugation: FITC
• Database Link:
  Entrez Gene 8794 Human
• Background: CD263 is a member of the tumour necrosis factor (TNF) receptor superfamily that binds to TNF-related apoptosis inducing ligand (TRAIL). As the receptor does not possess cytoplasmic death domains it cannot induce apoptosis, but instead plays an important role in inhibiting TRAIL-induced apoptosis. CD263 is expressed in normal tissues including heart, skeletal tissues and peripheral blood neutrophils, but weakly expressed in tumour cells.
• Synonyms: Decoy receptor 1, TNFRSF10C, DCR1, LIT, TRID, TRAIL receptor 3, TRAIL-R3
• Note: The 2B8 antibody does not inhibit DcR1 (CD263) inhibitory function in TRAIL-induced apoptosis.