DcR1 (TNFRSF10C) Mouse Monoclonal Antibody [Clone ID: 2B8]

CAT#: AM01323RP-N

DcR1 (TNFRSF10C) mouse monoclonal antibody, clone 2B8, PE

Specifications

Product Data

• Clone Name: 2B8
• Applications: FC
• Recommended Dilution: Flow Cytometry: 1/10; use 10µl of the suggested working dilution to label 1x10e6 cells in 100µl.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: DcR1-Fc chimaeric protein
• Specificity: This antibody recognises CD263, a 60 Kd cell surface protein, which is otherwise known as decoy receptor 1 (DcR1). The 2B8 antibody does not inhibit DcR1 (CD263) inhibitory function in TRAIL-induced apoptosis.
• Formulation: Phosphate buffered saline pH7.4 containing 0.09% Sodium Azide (NaN3), 1% Bovine Serum Albumin
  Label: PE
  State: Lyophilised purified IgG
  Label: R. Phycoerythrin (RPE)
• Reconstitution Method: Reconstitute with 1.0ml distilled water.
• Concentration: 0.1mg/ml
• Purification: Affinity chromatography on Protein G
• Conjugation: PE
• Database Link:
  Entrez Gene 8794 Human
• Background: CD263 is a member of the tumour necrosis factor (TNF) receptor superfamily that binds to TNF-related apoptosis inducing ligand (TRAIL). As the receptor does not possess cytoplasmic death domains it cannot induce apoptosis, but instead plays an important role in inhibiting TRAIL-induced apoptosis. CD263 is expressed in normal tissues including heart, skeletal tissues and peripheral blood neutrophils, but weakly expressed in tumour cells.
• Synonyms: Decoy receptor 1, TNFRSF10C, DCR1, LIT, TRID, TRAIL receptor 3, TRAIL-R3