Complement C3 (C3) Mouse Monoclonal Antibody [Clone ID: 10-21]

CAT#: AM01325PU-N

Complement C3 (C3) mouse monoclonal antibody, clone 10-21, Purified

Specifications

Product Data

• Clone Name: 10-21
• Applications: ELISA, WB
• Recommended Dilution: Western Blot.
  ELISA: 1/1500-1/6000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Native purified Human C3a.
• Specificity: This antibody recognizes 9 kDa complement component 3a (C3a) which is present in the blood serum.
  The antibody shows minimal reactivity with other complement proteins in radioimmunoassays and haemagglutination.
• Formulation: Borate buffered saline, pH8.2 containing 0.09% Sodium Azide as preservative
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement component 3 (C3)
• Database Link:
  Entrez Gene 718 Human
• Background: C3a is generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3a and C3b, which is further degraded into iC3b and C3dg/C3d. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. C3a mediates local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3a is expressed at significantly higher levels in colorectal cancer.
• Synonyms: CPAMD1, Complement component 3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Complement and coagulation cascades, Systemic lupus erythematosus