Complement factor B (CFB) (Bb Fragment) Mouse Monoclonal Antibody [Clone ID: 10-09]

CAT#: AM01333PU-N

Complement factor B (CFB) (Bb Fragment) mouse monoclonal antibody, clone 10-09, Purified

Specifications

Product Data

• Clone Name: 10-09
• Applications: ELISA, FC, IHC, WB
• Recommended Dilution: ELISA: This antibody binds to both the Bb fragment and complement factor B so is not suitable for all ELISA applications.
  Western Blot.
  Flow Cytometry.
  Immunohistochemistry on frozen sections.
  Recommended Positive Control: Kidney from post streptocial glomerlulonephritis patients.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human factor B
• Specificity: This antibody recognises the Bb fragment of 90 kDa complement factor B, present in blood serum.
• Formulation: Borate buffered saline containing 0.09% Sodium Azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement factor B (CFB)
• Database Link:
  Entrez Gene 629 Human
• Background: C3b associates with complement factor B, inducing conformational change which enables complement factor D to cleave the N-terminal of complement factor B, the Ba subunit, leaving the 63 kDa Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation.
• Synonyms: Properdin factor B, C3/C5 convertase, PBF2, CFB, BF, BFD

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades