Complement C4A (C4A) (neoepitope) Mouse Monoclonal Antibody [Clone ID: 057-51.5.1.6]

CAT#: AM01350PU-N

Complement C4A (C4A) (neoepitope) mouse monoclonal antibody, clone 057-51.5.1.6, Purified

Specifications

Product Data

• Clone Name: 057-51.5.1.6
• Applications: ELISA, FC, IHC
• Recommended Dilution: ELISA.
  Flow Cytometry.
  Immunohistochemistry on Frozen Sections.
  Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified Human C4d.
• Specificity: This antibody recognizes a neoantigen on the secreted protein complement component 4d (C4d).
• Formulation: Borate buffered saline
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement component 4A (Rodgers blood group) (C4A), transcript variant 1
• Database Link:
  Entrez Gene 720 Human
• Background: The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4bs alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation. C4 has been linked to susceptibility to systemic lupus erythematosous.
• Synonyms: Complement component 4, CPAMD2, CPAMD3, Acidic complement C4, Basic complement C4

Reference Data

• Protein Pathways: Complement and coagulation cascades, Systemic lupus erythematosus