Complement Component 6 (C6) Mouse Monoclonal Antibody [Clone ID: 056B-214.2.4.2]

CAT#: AM01357PU-N

Complement Component 6 (C6) mouse monoclonal antibody, clone 056B-214.2.4.2, Purified

Specifications

Product Data

• Clone Name: 056B-214.2.4.2
• Applications: ELISA, FC, IHC
• Recommended Dilution: ELISA.
  Flow Cytometry.
  Immunohistochemistry on Frozen Sections.
  Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified Human C6
• Specificity: This antibody recognizes complement component 6 (C6).
  This antibody recognizes MAC.
• Formulation: Borate buffered saline pH 8.2-8.4 containing 0.02% Sodium Azide as preservative
  State: Purified
  State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement component 6 (C6), transcript variant 1
• Database Link:
  Entrez Gene 729 Human
• Background: C6 is a 104 kDa member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C terminus of the C5b alpha-chain, anchoring the molecule to the membrane and also binds complement component 7. This enables the formation of the C5b-7 precursor complex. C5b-7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection.
• Synonyms: C6

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus