Syndecan 1 (SDC1) Mouse Monoclonal Antibody [Clone ID: B-A38]

CAT#: AM03022AF-N

Syndecan 1 (SDC1) mouse monoclonal antibody, clone B-A38, Azide Free

Product Images

Flow cytometry: A typical staining pattern using U266 cell line with the B-A38 monoclonal antibody no.

Specifications

Product Data

• Clone Name: B-A38
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry.
  Immunohistochemistry (1/50).
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: U266 cell line.
  Myeloma X63/AG.8653 x Balb/c spleen cells.
• Specificity: The antibody B-A38 recognizes CD138 (Syndecan-1), a 65-70 kDa heparan sulfate proteoglycan expressed mainly in the epidermis and plasma cells, but also in growth factor-stimulated lymphocytes.
• Formulation: Azide Free PBS, pH 7.4, 0.2 μm filter sterilized
  State: Azide Free
  State: Liquid purified Ig fraction
  Preservative: None
• Concentration: 1.0 mg/ml
• Purification: Ion Exchange Chromatography
• Gene Name: Homo sapiens syndecan 1 (SDC1), transcript variant 1
• Database Link:
  Entrez Gene 6382 Human
• Background: CD138 (syndecan-1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.
• Synonyms: SYND1, SDC1, SDC

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), ECM-receptor interaction