DcR2 (TNFRSF10D) Mouse Monoclonal Antibody [Clone ID: TRAIL-R4-01]

CAT#: AM03039FC-N

DcR2 (TNFRSF10D) mouse monoclonal antibody, clone TRAIL-R4-01, FITC


USD 355.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name TRAIL-R4-01
Applications FC
Recommended Dilution Flow Cytometry: 3 µg/ml.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen TRAIL-R4 (aa 1-210) - hIgGhc fusion protein
Specificity The antibody TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
Formulation PBS containing 15 mM Sdium Azide as preservative and 0.2% (w/v) high-grade (Protease free) BSA as a stabilizing agent.
Label: FITC
State: Liquid purified IgG fraction.
Label: Fluorescein Isothiocyanate Isomer 1
Concentration 0.1 mg/ml
Conjugation FITC
Gene Name Homo sapiens tumor necrosis factor receptor superfamily member 10d (TNFRSF10D)
Background TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).
Synonyms TNFRSF10D, DCR2, TRAIL-R4, TRUNDD, Decoy receptor 2, TRAIL receptor 4
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.