DcR2 (TNFRSF10D) Mouse Monoclonal Antibody [Clone ID: TRAIL-R4-01]

CAT#: AM03039RP-N

DcR2 (TNFRSF10D) mouse monoclonal antibody, clone TRAIL-R4-01, PE

Specifications

Product Data

• Clone Name: TRAIL-R4-01
• Applications: FC
• Recommended Dilution: Flow Cytometry: 3 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: TRAIL-R4 (aa 1-210) - hIgGhc fusion protein
• Specificity: The antibody TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
• Formulation: PBS containing 15 mM Sdium Azide as preservative and 0.2% (w/v) high-grade (Protease free) BSA as a stabilizing agent.
  Label: PE
  State: Liquid purified IgG fraction.
  Label: R-Phycoerythrin under optimum conditions
• Concentration: 0.1 mg/ml
• Purification: Size-Exclusion Chromatography.
• Conjugation: PE
• Gene Name: Homo sapiens tumor necrosis factor receptor superfamily member 10d (TNFRSF10D)
• Database Link:
  Entrez Gene 8793 Human
• Background: TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).
• Synonyms: TNFRSF10D, DCR2, TRAIL-R4, TRUNDD, Decoy receptor 2, TRAIL receptor 4

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity