DAXX Mouse Monoclonal Antibody [Clone ID: DAXX-03]

CAT#: AM03040PU-N

DAXX mouse monoclonal antibody, clone DAXX-03, Aff - Purified


USD 240.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name DAXX-03
Applications IF, IP, WB
Recommended Dilution Immunoprecipitation.
Western Blotting: 2 μg/ml.
Immunocytochemistry.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen His6-tagged protein corresponding to amino acids 580-740 of human Daxx.
Specificity The antibody DAXX-03 reacts with C-terminal part of Daxx, a 110 kDa intracellular protein.
Formulation PBS, pH 7.4 with 15 mM sodium azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration lot specific
Purification Protein A affinity chromatography.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Daxx is an apoptosis-modulating death-domain associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).
Synonyms BING2, DAP6, EAP1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.