CD300 antigen (CD300A) Mouse Monoclonal Antibody [Clone ID: MEM-260]

CAT#: AM03062RP-N

CD300 antigen (CD300A) mouse monoclonal antibody, clone MEM-260, PE

Product Images

Surface staining of human peripheral blood cells with anti-CD300a (MEM-260) PE.

Specifications

Product Data

• Clone Name: MEM-260
• Applications: FC
• Recommended Dilution: Suitable for Flow Cytometry analysis of Human blood cells using 20 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension.
  The content of a vial (2 ml) is sufficient for 100 tests.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: HPB Human acute lymphoid leukemia cell line
• Specificity: The antibody reacts with CD300a, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25% of circulating T cells and 15% of circulating B cells.
• Formulation: Phosphate buffered saline (PBS) solution containing 15mM sodium azide
  Label: PE
  State: Liquid purified IgG fraction
  Label: Conjugated with R-Phycoerythrin under optimum conditions
• Purification: Size-Exclusion Chromatography
• Conjugation: PE
• Database Link:
  Entrez Gene 11314 Human
• Background: CD300a (CMRF-35H, IRp60) is a non-MHC-specific inhibitory receptor of immunoglobulin superfamily, which contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that associate with SH2-containing phosphatases SHP-1 and SHP-2. CD300a is expressed on many cell types including T cells, NK cells, neutrophils, eosinophils or mast cells. Its triggering inhibits activating signals such as those of IL5, GM-CSF or eotaxin, as well as supresses mast cell degranulation or NK cell cytotoxic activity.
• Synonyms: CLM-8, CMRF35-H, CMRF35-H9, CMRF-35-H9, IRC1/IRC2, IRp60