CD21 (CR2) Mouse Monoclonal Antibody [Clone ID: LT21]

CAT#: AM03064PU-N

CD21 (CR2) mouse monoclonal antibody, clone LT21, Purified

Product Images

Double staining of human, canine and porcine B lymphocytes with anti-CD79a (HM57) and anti-CD21 (LT21) antibody.

Specifications

Product Data

• Clone Name: LT21
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry: 2µg/ml.
  Immunohistochemistry on frozen sections.
• Reactivities: Bovine, Canine, Human, Porcine
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: IM9 human B-lymphoblastoid cell line
• Specificity: The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells.
• Formulation: PBS, pH 7.4 containing 15 mM sodium azide as preservative
  State: Purified
  State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE)
• Concentration: lot specific
• Purification: Precipitation methods and Ion exchange chromatography
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: complement component 3d receptor 2
• Database Link:
  Entrez Gene 1380 Human
• Background: CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
• Synonyms: Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic Cell Marker