CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: MEM-229]

CAT#: AM03092FC-N

CD105 (ENG) mouse monoclonal antibody, clone MEM-229, FITC


USD 270.00

2 Weeks*

Size
    • 100 Tests

Product Images

Specifications

Product Data
Clone Name MEM-229
Applications FC, IF
Recommended Dilution Flow Cytometry analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 106 cells in a suspension. 
The Content of vial (2 ml) is sufficient for 100 Tests.
Reactivities Human, Porcine
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA
Specificity This antibody recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Formulation PBS
Label: FITC
State: Liquid purified Ig fraction
Stabilizer: 0.2% (w/v) high-grade protease free BSA
Preservative: 15 mM Sodium Azide
Label: Conjugated with Fluorescein isothiocyanate
Conjugation FITC
Storage Store udniluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Gene Name endoglin
Background CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbR-2 as a receptor for TGFb-1 and TGFb-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFb-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Synonyms ENG, END, HHT1, ORW, ORW1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.