CD22 Mouse Monoclonal Antibody [Clone ID: IS7]
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Specifications
Product Data | |
Clone Name | IS7 |
Applications | FC |
Recommended Dilution | Flow Cytometry analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Reh human cell line |
Specificity | This antibody reacts with CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes. |
Formulation | Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. Label: PE State: Liquid Ig fraction Label: Conjugated with R-Phycoerythrin under optimum conditions |
Purification | Size-exclusion chromatography |
Conjugation | PE |
Storage | Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
Stability | Shelf life: one year from despatch. |
Gene Name | CD22 molecule |
Database Link | |
Background | CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway. |
Synonyms | SIGLEC2, Siglec-2, B-cell receptor CD22, Leu-14, BL-CAM |
Reference Data |
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