Il2 Rat Monoclonal Antibody [Clone ID: I2-C7]

CAT#: AM05018PU-N

Il2 rat monoclonal antibody, clone I2-C7, Azide Free

Specifications

Product Data

• Clone Name: I2-C7
• Applications: FN
• Recommended Dilution: A 1:50 dilution will block 50 - 70% of CTLL proliferative response to 5% Con A sup as a source for mouse IL-2. This antibody will also block 50 - 70% of MLR or T cell proliferation to KLH
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Mouse IL-2 purified from Con A activated T cell supernatant
• Specificity: This antibody reacts to IL-2. Does not cross react with rat or human IL-2.
• Formulation: PBS
  State: Azide Free
  State: Lyophilized purified Ig
• Reconstitution Method: Restore with 0.2ml water. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
• Concentration: lot specific
• Purification: Protein A/S-Sepharose
• Storage: Prior to reconstitution store at 2-8°C.
  Following reconstitution store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 16183 Mouse
• Background: Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.
• Synonyms: IL-2, TCGF