TNF

CAT#: AM05246BT-N

Mouse Monoclonal Anti-TNF Antibody, Biotinylated

Specifications

Product Data

• Clone Name: AS1
• Applications: E
• Recommended Dilution: ELISA
• Reactivities: Human, Monkey
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human recombinant tumor necrosis factor alpha.
• Specificity: Recognizes human TNF alpha.
  This antibody also binds baboon TNF alpha.
  Does not recognize human TNF beta, mouse TNF alpha or a panel of other human cytokines.
• Formulation: PBS containing 0.08% Sodium Azide as preservative.
• Concentration: lot specific
• Purification: Protein G chromatography (> 95 % by SDS-PAGE).
• Conjugation: Biotin
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
  Shelf life: one year from despatch.
• Predicted Protein Size: 25.5 kDa
• Gene Name: tumor necrosis factor
• Database Link:
  NP_000585
  Entrez Gene 7124 Human
  UniProt ID P01375
• Background: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
• Synonyms: Cachectin; DIF; TNF-a; TNF-alpha; TNFA; TNFSF2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway, Allograft rejection, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Asthma, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Fc epsilon RI signaling pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Natural killer cell mediated cytotoxicity, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus, Type II diabetes mellitus