TNF
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Specifications
Product Data | |
Clone Name | AS1 |
Applications | E |
Recommended Dilution | ELISA |
Reactivities | Human, Monkey |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant tumor necrosis factor alpha. |
Specificity | Recognizes human TNF alpha. This antibody also binds baboon TNF alpha. Does not recognize human TNF beta, mouse TNF alpha or a panel of other human cytokines. |
Formulation | PBS containing 0.08% Sodium Azide as preservative. |
Concentration | lot specific |
Purification | Protein G chromatography (> 95 % by SDS-PAGE). |
Conjugation | Biotin |
Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
Predicted Protein Size | 25.5 kDa |
Gene Name | tumor necrosis factor |
Database Link | |
Background | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. |
Synonyms | Cachectin; DIF; TNF-a; TNF-alpha; TNFA; TNFSF2 |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane |
Protein Pathways | Adipocytokine signaling pathway, Allograft rejection, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Asthma, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Fc epsilon RI signaling pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Natural killer cell mediated cytotoxicity, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus, Type II diabetes mellitus |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.