IL6 Rat Monoclonal Antibody [Clone ID: MQ2-39C3]

CAT#: AM05404BT-N

IL6 rat monoclonal antibody, clone MQ2-39C3, Biotin

Specifications

Product Data

• Clone Name: MQ2-39C3
• Applications: ELISA
• Recommended Dilution: ELISA: this antibody may be used in a Direct ELISA or as the detection reagent in a Sandwich ELISA with AM05403PU-N as the capture antibody.
• Reactivities: Human
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: This antibody recognises Interleukin 6.
• Formulation: Phosphate buffered saline containing 0.09% Sodium Azide as preservative.
  Label: Biotin
  State: Liquid purified IgG fraction.
• Concentration: lot specific
• Conjugation: Biotin
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 6
• Database Link:
  Entrez Gene 3569 Human
• Background: Interleukin 6 (IL6) is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass.
  
  IL6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. In addition, IL6 appears to interact with IL2 in the proliferation of T lymphocytes. IL6 potentiates the proliferative effect of IL3 on multipotential hematopoietic progenitors.
• Synonyms: IL-6, Interferon beta-2, IFNB2, B-cell stimulatory factor 2, BSF-2, CDF