Itgax Hamster Monoclonal Antibody [Clone ID: N418]

CAT#: AM05514FC-N

Itgax hamster monoclonal antibody, clone N418, FITC


USD 415.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name N418
Applications FC
Recommended Dilution Flow Cytometry: 1/100; use 10µl of the suggested working dilution to label 10e6 cells in 100µl; The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.
Reactivities Mouse
Host Hamster
Isotype IgG
Clonality Monoclonal
Immunogen Mouse spleen dendritic cells.
Specificity This antibody recognises the murine homologue of human CD11c, which is a 150/90kD member of the beta 2 integrin family. In mice, CD11c is primarily expressed by dendritic cells. Clone N418 has been reported to enhance antigen specific responses when used to target dendritic cells in vivo.
Formulation Phosphate buffered saline pH7.4 containing 0.09% Sodium Azide, 1% Bovine Serum Albumin
Label: FITC
State: Liquid purified IgG
Label: Fluorescein Isothiocyanate Isomer 1
Concentration 0.1 mg/ml
Purification Affinity chromatography on Protein G
Conjugation FITC
Background CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue.
Synonyms ITGAX, Integrin alpha-X, Leu M5
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.