Itgax Hamster Monoclonal Antibody [Clone ID: N418]

CAT#: AM05514PU-T

Itgax hamster monoclonal antibody, clone N418, Purified

Specifications

Product Data

• Clone Name: N418
• Applications: FC, IHC, IP
• Recommended Dilution: Immunohistochemistry on Frozen Sections.
  Immunoprecipitation.
  Flow Cytometry: Use 10 µl of 1/25-1/100 diluted antibody to label 1x10⁶ cells in 100 µl.
• Reactivities: Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Mouse spleen dendritic cells.
• Specificity: This antibody recognises the murine homologue of Human CD11c, which is a 150/90kD member of the beta 2 integrin family. In mice, CD11c is primarily expressed by dendritic cells.
  Clone N418 has been reported to enhance antigen specific responses when used to target dendritic cells in vivo. (Ref.3)
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography on Protein G.
• Database Link:
  Entrez Gene 16411 Mouse
• Background: CD11c (integrin alpha X chain protein) combines with the beta 2 chain (ITGB2) to form a leukocyte specific integrin referred to as inactivated C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. The CD11c antigen is a marker for hairy cell leukaemia.
• Synonyms: ITGAX, Integrin alpha-X, Leu M5