ITGAM Mouse Monoclonal Antibody [Clone ID: CC126]

CAT#: AM05517FC-N

ITGAM mouse monoclonal antibody, clone CC126, FITC

Specifications

Product Data

• Clone Name: CC126
• Applications: FC
• Recommended Dilution: Flow Cytometry: 1/10; use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
• Reactivities: Bovine, Goat, Sheep
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Specificity: This antibody recognises the CD11b cell surface antigen.
• Formulation: PBS
  Label: FITC
  State: Liquid purified IgG
  Stabilizer: 1% BSA
  Preservative: 0.09% Sodium Azide
  Label: Fluorescein Isothiocyanate Isomer 1
  Absorption emission: 490 nm / 525 nm
• Concentration: 0.1 mg/ml
• Purification: Affinity chromatography on Protein G
• Conjugation: FITC
• Background: CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue.
• Synonyms: ITGAM, CR3A, CR-3 alpha chain, Integrin alpha-M, MAC1