CD70 Mouse Monoclonal Antibody [Clone ID: Bu69]

CAT#: AM05527PU-N

CD70 mouse monoclonal antibody, clone Bu69, Purified

Specifications

Product Data

• Clone Name: Bu69
• Applications: FC, IHC
• Recommended Dilution: Immunohistochemistry on frozen sections.
  Flow Cytometry: 1/50 - 1/200.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: This antibody recognises CD70, a 29kD type II transmembrane protein that belongs to the tumour necrosis factor (TNF) family. CD70 is expressed on a small number of activated T-cells and the majority of activated B-cells. Interaction of CD70 with its receptor, CD27, is thought to play an important role in lymphocyte activation, proliferation, survival and differentiation.
• Formulation: PBS, pH7.4 containing 0.09% Sodium Azide as preservative
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein G
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens CD70 molecule (CD70)
• Database Link:
  Entrez Gene 970 Human
• Background: CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
• Synonyms: CD27 ligand, CD27L, CD27LG, TNFSF7

Reference Data

• Protein Families: ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction