CD321 / JAM1 Rat Monoclonal Antibody [Clone ID: BV12]
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Product Data | |
Clone Name | BV12 |
Applications | ELISA, FC, IF |
Recommended Dilution | Flow cytometry: The typical starting working dilution is 1:50. Immunoassays. Immunoflourescence. |
Reactivities | Mouse |
Host | Rat |
Isotype | IgG2a |
Clonality | Monoclonal |
Specificity | This antibody recognizes junctional adhesion molecule-A (JAM-A), also known as JAM-1 and the mouse platelet F11-Receptor (F11R). |
Formulation | PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide |
Concentration | 0.1 mg/ml |
Purification | Protein G |
Background | JAM-A is a member of the immunoglobulin superfamily found on the surface of mouse platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-B (VE-JAM or JAM-3) and JAM-C (JAM-2) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. In human JAM-A plays a role in platelet aggregation, secretion, adhesion and spreading. |
Synonyms | JAM-A, Platelet F11 receptor, F11R, JCAM, PAM1 |
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