CD51 / ITGAV Rat Monoclonal Antibody [Clone ID: RMV-7]

CAT#: AM05569RP-N

CD51 / ITGAV rat monoclonal antibody, clone RMV-7, PE

Specifications

Product Data

• Clone Name: RMV-7
• Applications: FC
• Recommended Dilution: Flow Cytometry: 1/10.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: cultured LAK cells from Balb/c mice.
• Specificity: This antibody recognises CD51. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.
• Formulation: Phosphate buffered saline pH7.4 containing 0,09% sodium azide
  Label: PE
  State: Lyophilised purified IgG
  Label: R. Phycoerythrin (RPE)
• Reconstitution Method: Reconstitute with 1ml distilled water
• Concentration: lot specific
• Purification: Affinity chromatography on Protein G
• Conjugation: PE
• Storage: Prior to and following reconstitution store the antibody at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Background: CD51 is a 140 kD alpha subunit of the vitronectin receptor, which is otherwise known as the intergrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61. Heterodimers of CD51/CD61 functions as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing.
• Synonyms: Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha