Cd80 Rat Monoclonal Antibody [Clone ID: RM80]
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Specifications
Product Data | |
Clone Name | RM80 |
Applications | FC |
Recommended Dilution | Flow Cytometry: Use 10 µl of neat antibody to label 1x10e6 cells in 100 µl. |
Reactivities | Mouse |
Host | Rat |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | BCL1 cells expressing CD80. |
Specificity | This antibody recognises CD80 (B7-1), a 60kD cell surface glycoprotein which is a member of the CD28/B7 family. In mice, CD80 is expressed on monocytes, peritoneal macrophages and dendritic cells. Expression may be significantly increased upon B lymphocytes by LPS and by IL-4. |
Formulation | Phosphate buffered saline, pH 7.4 containing 0,09% sodium Azide as preservative and 1% BSA as stabilizer. Label: FITC State: Liquid purified Ig fraction. Label: Fluorescein Isothiocyanate Isomer 1 |
Concentration | 0.1 mg/ml |
Purification | Affinity Chromatography on Protein G. |
Conjugation | FITC |
Database Link | |
Background | CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines. |
Synonyms | CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1 |
Reference Data |
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