Cd86 Rat Monoclonal Antibody [Clone ID: PO3]

CAT#: AM05571RP-T

Cd86 rat monoclonal antibody, clone PO3, PE

Specifications

Product Data

• Clone Name: PO3
• Applications: FC
• Recommended Dilution: Flow Cytometry: 1/10.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Mouse B-cell line, BCL1.
• Specificity: This antibody recognises CD86 (B7-2). The PO3 clone has been reported to block some co-stimulatory functions of CD86.
• Formulation: Phosphate buffered saline pH7.4 containing 0.09% Sodium Azide, 1% Bovine Serum Albumin
  Label: PE
  State: Lyophilised purified IgG
  Label: R. Phycoerythrin (RPE)
• Reconstitution Method: Reconstitute with 0,25 ml distilled water
• Concentration: 0,1 mg/ml
• Purification: Affinity chromatography on Protein G
• Conjugation: PE
• Database Link:
  Entrez Gene 12524 Mouse
• Background: CD86 is an 80kD cell surface glycoprotein which is a member of the CD28/B7 family. In mouse, CD86 is expressed at high levels on peripheral blood monocytes, dendritic cells and at low levels on resting B and T-lymphocytes. Expression of CD86 on these cell populations can be increased upon activation. CD86 has been identified, along with CD80 (B7-1) as a ligand for CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA4). CD28 and CTLA4 are two receptors that have opposing functions in T-cell stimulation. Interaction of CD86 with CD28 promotes a number of T-cell activities, whereas the binding of CD86 to CTLA4 inhibits T-cell responses.
• Synonyms: CD28LG2, Activation B7-2 antigen, B70, BU63, B7.2, FUN-1