Complement factor B (CFB) (Bb Fragment) Mouse Monoclonal Antibody [Clone ID: 032B-22.1.X]

CAT#: AM05624PU-N

Complement factor B (CFB) (Bb Fragment) mouse monoclonal antibody, clone 032B-22.1.X, Purified

Specifications

Product Data

• Clone Name: 032B-22.1.X
• Applications: ELISA, FC, WB
• Recommended Dilution: Flow Cytometry.
  ELISA.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Binds neoantigen of fragment Bb from human complement factor B.
• Specificity: This antibody recognises a neoantigen of the Bb fragment of complement factor B.
• Formulation: Borate buffered saline pH8.2 - 8.4 containing 0.02% Sodium Azide (NaN3)
  State: Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement factor B (CFB)
• Database Link:
  Entrez Gene 629 Human
• Background: Factor B is present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit) leaving the 63 kDa Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation.
• Synonyms: Properdin factor B, C3/C5 convertase, PBF2, CFB, BF, BFD

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades