Cd8a Rat Monoclonal Antibody [Clone ID: 53-6.7]

CAT#: AM05640RP-N

Cd8a rat monoclonal antibody, clone 53-6.7, PE

Specifications

Product Data

• Clone Name: 53-6.7
• Applications: FC
• Recommended Dilution: Flow Cytometry.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Mouse thymus or spleen.
• Specificity: This antibody detects CD8a, the alpha chain of the CD8 antigen. CD8 is expressed on T-cells, and exists either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain.
  The 53-6.7 antibody has been reported to block antigen presentation via MHC class I and inhibit T cell responses to IL-2.
  This antibody has also been used for depletion of CD8a+ cells.
• Formulation: PBS, pH 7.2
  Label: PE
  State: Liquid purified IgG fraction
  Stabilizer: 1% BSA
  Preservative: 0.09% Sodium Azide
  Label: R. Phycoerythrin (RPE)
• Purification: Affinity Chromatography on Protein G
• Conjugation: PE
• Database Link:
  Entrez Gene 12525 Mouse
• Background:
  The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
  
  CD8 functions as a co-receptor with the T-cell receptor and mediates efficient cell to cell interactions within the immune system. The CD8 alpha chain specifically binds to class I MHC molecules.
• Synonyms: CD8 alpha chain, CD8A, MAL