Il6 Rat Monoclonal Antibody [Clone ID: 6B4 IGH 54]

CAT#: AM05676AF-N

Il6 rat monoclonal antibody, clone 6B4 IGH 54, Azide Free

Specifications

Product Data

• Clone Name: 6B4 IGH 54
• Applications: ELISA, FN
• Recommended Dilution: ELISA.
  Functional Assays: 3 µg/ml.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Natural partially purified mouse IL-6.
• Specificity: This antibody is specific for IL-6 (interleukin-6). Clone 6B4 IGH 54 can be used to neutralise the activity of 50pg/ml of recombinant mouse IL-6 by >95% in a functional assay.
• Formulation: Phosphate buffered saline
  State: Azide Free
  State: Liquid purified IgG
• Concentration: 1.0mg/ml
• Purification: Affinity chromatography on protein G
• Gene Name: interleukin 6
• Database Link:
  Entrez Gene 16193 Mouse
• Background: IL-6 is a multifunctional pro-inflammatory cytokine secreted by activated T cells, macrophages, endothelial cells, fibroblasts and osteoblasts, which acts as the principle inducer of the acute phase response in the liver.
  IL-6 signals through a membrane bound receptor complex consisting of the ligand-binding IL-6Ra chain (CD126) and the signal-transducing component gp130 (CD130), but can also stimulate cells expressing gp130 through a soluble IL-6R. IL-6 has been shown to stimulate B cell differentiation and subsequent immunoglobulin production, promote hybridoma growth, as well as regulating bone metabolism and stimulating energy mobilisation in muscle and fatty tissue.
• Synonyms: IL-6, Interferon beta-2, IFNB2, B-cell stimulatory factor 2, BSF-2, CDF
• Note: Endotoxin Level < 0.004EU/µg