IL4 Mouse Monoclonal Antibody [Clone ID: CC303]

CAT#: AM05868RP-N

IL4 mouse monoclonal antibody, clone CC303, PE

Specifications

Product Data

• Clone Name: CC303
• Recommended Dilution: Flow Cytometry: 1/5.
• Reactivities: Bovine, Canine, Goat, Porcine, Sheep, Mustelid
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: This antibody recognises bovine interleukin 4.
• Formulation: Phosphate buffered saline pH7.4 containing 0.09% Sodium Azide, 1% Bovine Serum Albumin
  Label: PE
  State: Lyophilised purified IgG
  Label: R. Phycoerythrin (RPE)
• Reconstitution Method: Reconstitute with 1 ml distilled water
• Concentration: lot specific
• Purification: Affinity chromatography on Protein G
• Conjugation: PE
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Background: IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Synonyms: IL-4, BSF1, Lymphocyte stimulatory factor 1, Binetrakin, Pitrakinra