Ltbr Rat Monoclonal Antibody [Clone ID: 5G11b]

CAT#: AM05877LE-N

Ltbr rat monoclonal antibody, clone 5G11b, Low Endotoxin

Specifications

Product Data

• Clone Name: 5G11b
• Applications: FC, FN
• Recommended Dilution: Flow cytometry: 1/50 - 1/100.
  Functional assays.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant extracellular domain of LT beta R
• Specificity: This antibody recognises lymphotoxin-beta receptor (LT beta R), a member of the tumour necrosis factor family. LT beta R is primarily expressed on stromal cells and fibroblasts and at lower levels on myeloid cell lines. Clone 5G11b specifically recognises surface expressed LT beta R. The clone is reported to be agonistic with respect to NF Kappa B activation, MIP-2 induction and IL-6 release (2).
  This product is routinely tested by flow cytometry on mouse WEH1 cells.
• Formulation: Phosphate buffered saline pH 7.4, azide free
  State: Low Endotoxin
  State: Liquid Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography on Protein G
• Gene Name: lymphotoxin B receptor
• Database Link:
  Entrez Gene 17000 Mouse
• Background: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin alpha and lymphtoxin beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
• Synonyms: Tumor necrosis factor receptor 3, TNF-R3, Tumor necrosis factor C receptor, TNFCR, TNFRSF3, D12S370, Lymphotoxin-beta receptor