LAMP1 Mouse Monoclonal Antibody [Clone ID: 4E9/11]

CAT#: AM05888FC-N

LAMP1 mouse monoclonal antibody, clone 4E9/11, FITC


USD 705.00

5 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 4E9/11
Applications FC
Recommended Dilution Flow Cytometry: Use 10 µl of Neat antibody to label 10e6 cells in 100 µl (Membrane permeabilisation is required).
Reactivities Porcine
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Porcine alveolar Macrophages.
Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63-Ag.8.653 myeloma cell line.
Specificity This antibody is specific for Porcine CD107a, a cell surface antigen that is also known as lysosomal-associated membrane protein-1 (LAMP-1).
CD107a is expressed on macrophages and more weakly on monocytes and granulocytes.
Formulation PBS, pH 7.4
Label: FITC
State: Liquid purified IgG fraction
Stabilizer: 1% BSA
Preservative: 0.09% Sodium Azide
Label: Fluorescein Isothiocyanate Isomer 1
Concentration 0.1 mg/ml
Purification Affinity Chromatography on Protein G
Conjugation FITC
Gene Name -
Background Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
Synonyms LAMP-1, LAMPA, LGP120
Reference Data

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