CIB1 Mouse Monoclonal Antibody [Clone ID: 5A1F5E12]

CAT#: AM06136SU-N

CIB1 mouse monoclonal antibody, clone 5A1F5E12, Ascites

Product Images

Western blot analysis using CIB1 antibody Cat.-No AM06136SU-N against truncated CIB1 recombinant protein (Lane 1) and A431 cell lysate (Lane 2).

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  Immunohistochemical analysis of paraffin-embedded human thalamus (left) and glioma (right) tissue, showing membrane localization using CIB1 antibody Cat.-No AM06136SU-N with DAB staining.

Specifications

Product Data

• Clone Name: 5A1F5E12
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Blot: 1/500 - 1/2000.
  Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
  
• Reactivities: Human
• Host: Mouse
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of CIB1 expressed in E. Coli.
• Formulation: State: Ascites
  State: Ascitic fluid
  Preservative: 0.03% Sodium Azide
• Gene Name: calcium and integrin binding 1
• Database Link:
  Entrez Gene 10519 Human
• Background: CIB1 (also designated calcium and integrin binding 1 or calmyrin),with 191-amino acid protein(about 21kDa), belongs to the calcium-binding protein family.CIB1 is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining.CIB1 is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alpha(IIb)beta(3) integrin and several serine/threonine kinases and potentially modulates their function.CIB1 regulates platelet aggregation in hemostasis through a specific interaction with the alpha(IIb) cytoplasmic domain of platelet integrin alpha(IIb)beta(3). CIB1 is also ubiquitously expressed activating and inhibiting protein ligand of the InsP3R.
• Synonyms: Calmyrin, KIP, PRKDCIP, SIP2-28, CIBP